Patient Education - Endocrine Encyclopedia
Endocrine Surgery Encyclopedia
An aldosterone test measures the amount of aldosterone in serum (blood).
How the test is performed:
Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand.
The puncture site is cleaned with antiseptic. An elastic band is placed around the upper
arm to apply pressure and cause the vein to swell with blood.
A needle is inserted into the vein, and the blood is collected in an air-tight vial or
a syringe. During the procedure, the band is removed to restore circulation. Once the blood
has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
For infants or young children, the area is cleansed with antiseptic and punctured with
a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on
a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture
site if there is any bleeding.
How to prepare for the test:
Your doctor may provide instructions on dietary or supplemental salt intake prior to testing.
How the test will feel:
When the needle is inserted to draw blood, some people feel moderate pain, while others feel
only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performed:
This test is performed to investigate hard-to-control blood pressure, orthostatic hypotension
(low blood pressure upon standing), and certain fluid and electrolyte disorders.
Aldosterone is a hormone released by the adrenal glands. It is part of the complex mechanism
used by the body to regulate blood pressure. Aldosterone is the main sodium-retaining hormone
from the adrenal gland. It increases the reabsorption of sodium and water along with the
excretion of potassium in the distal tubules of the kidneys. This action raises blood pressure.
Frequently, blood aldosterone levels are combined with other blood tests (plasma renin
activity) or provocative tests (captopril test, intravenous saline infusion test or ACTH
infusion test) in order to diagnosis over- or under-production of the hormone.
Lying down: 2 to 16 ng/dl
Upright: 5 to 41 ng/dl
Normal value ranges may vary slightly among different laboratories.
Note: ng/dl = nanograms per deciliter
What abnormal results mean:
Higher-than-normal levels of aldosterone may indicate:
- Primary hyperaldosteronism (rare)
- Bartter syndrome (extremely rare)
- Secondary hyperaldosteronism from cardiac or kidney disease
- Cushing's syndrome (rare)
- Very low sodium diet
Lower-than-normal levels of aldosterone may indicate:
- Addison's disease (rare)
- Very high sodium diet
- Congenital adrenal hyperplasia
- Hyporeninemic hypoaldosteronism
What the risks are:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
- Multiple punctures to locate veins
Factors that can affect aldosterone measurements include strenuous exercise, acute stress,
and dietary salt intake.
Many medications can influence aldosterone levels, including diuretics, lithium, calcium
channel blockers, ACE inhibitors, propranolol, NSAIDs, and heparin.
Veins and arteries vary in size from one patient to another and from one side of the body
to the other. Obtaining a blood sample from some people may be more difficult than from others.
Review Date: 3/8/2006
Reviewed By: Robert Hurd, M.D., Department of Biology, College of Arts and Sciences, Xavier
University, Cincinnati, OH. Review provided by VeriMed Healthcare Network.
Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission
(www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M.
follows rigorous standards of quality and accountability. A.D.A.M. is among the first to
achieve this important distinction for online health information and services. Learn more
a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net
The information provided herein should not be used during any medical emergency or for
the diagnosis or treatment of any medical condition. A licensed medical professional should
be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for
all medical emergencies. Links to other sites are provided for information only -- they do
not constitute endorsements of those other sites. © 1997- 2007 A.D.A.M., Inc. Any duplication
or distribution of the information contained herein is strictly prohibited.