Welcome to...The UCLA Endocrine Surgical Unit
 

Schedule an Appointment
Endocrine Home
About Us
Our Expert Team
Our Services
First Visit for Patients
Patient Education
  Getting started
  High Calcium
  Parathyroid 4D-CT Scan
  Parathyroid Surgery Success
  Parathyroid Surgery Priorities
  Benefits of parathyroid surgery
  Thyroid and Parathyroid Disease
  Find a Surgeon
  Parathyroid Surgery FAQ
  About endocrine surgery
  History of endocrine surgery
  Outcomes in endocrine surgery
  Health Care Quality and Safety
  Reputable Affiliates
  Diseases we treat
  Endocrine encyclopedia
  Adrenocortical Carcinoma
  Pheochromocytoma
  Thyroid Cancer in Children
  Thyroid Cancer Staging
Scar Gallery
For Referring Physicians
Distance Surgery Program
International Patients
Insurance Questions
Map-Directions-Parking
Contact Us
Patient Experiences
Endocrine Resources
Fellowship Training
Research Opportunities
Site Map

UCLA Health System





Pheochromocytoma - Encyclopedia Information

Encyclopedia for Pheochromocytoma

Pheochromocytoma

Definition:
Pheochromocytoma is a tumor of the adrenal gland that causes excess release of epinephrine and norepinephrine, hormones that regulate heart rate and blood pressure.

Alternative Names: Chromaffin tumors

Causes, incidence, and risk factors:
Pheochromocytoma may occur as a single tumor or as multiple growths. It usually develops in the medulla (center or core) of one or both adrenal glands. Sometimes this kind of tumor occurs outside the adrenal gland, usually somewhere else in the abdomen. Less than 10% of pheochromocytomas are malignant (cancerous), with the potential to spread to other parts of the body.

The tumors may occur at any age, but they are most common from early to mid-adulthood. A common clinical feature is a paroxysm (an attack of symptoms listed below) that may be frequent but sporadic (occurring at unpredictable intervals). The paroxysms may increase in frequency, duration and severity as the tumor grows.

Symptoms:

  • Severe headache
  • Palpitations
  • Rapid heart rate
  • Sweating
  • Flushing
  • Chest pain
  • Abdominal pain
  • Nervousness
  • Irritability
  • Increased appetite
  • Loss of weight
  • Additional symptoms that may be associated with this disease:
  • Sleeping difficulty
  • Hand tremor
  • High blood pressure

Signs and tests:
Vital signs (temperature, pulse, rate of breathing, blood pressure) reveal high blood pressure (hypertension) that may be sustained or episodic, rapid heart rate, and elevated temperature.

Tests include:

  • An adrenal biopsy that shows pheochromocytoma
  • A MIBG scintiscan that shows tumor
  • An MRI of abdomen that shows adrenal mass
  • An abdominal CT scan that shows mass.
  • Elevated urine metanephrine
  • Elevated urine catecholamines
  • Abnormal results of a glucose test
  • Abnormal levels of catecholamines in the blood

Treatment:
The definitive treatment is removal of the tumor by surgery. Stabilization of the person's vital signs with medication prior to surgery is important, and may require hospitalization. After surgery, it is necessary to continually monitor all vital signs in an intensive care unit. In the case of an inoperable tumor, management with medication is necessary. Radiation therapy or chemotherapy have not been effective in curing this kind of tumor.

Support Groups:

Expectations (prognosis):
For patients who have non-cancerous tumors that are removed with surgery, 95% of these patients are still alive after 5 years. The tumors come back in less than 10% of these patients. Hormone secretion of norepinephrine and epinephrine returns to normal after surgery.

For patients who have cancerous tumors that are removed with surgery, less than 50% of patients are alive after 5 years.

Complications:
High blood pressure may not be cured in 25% of patients after surgery, yet control is usually achieved in these people with standard treatments for hypertension. Recurrence of tumor may occur in 10% of the cases.

Calling your health care provider:
Call your health care provider if you have symptoms of pheochromocytoma or if you have had a pheochromocytoma in the past and symptoms recur.

Prevention:



Review Date: 8/3/2004
Reviewed By: Marcia S. Brose, M.D., Ph.D., Assistant Professor, Hematology/Oncology, The University of Pennsylvania Cancer Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

A.D.A.M. qualityA.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2007 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

A.D.A.M. logo


Diseases of the Endocrine System

Tests and studies: