Patient Education - Endocrine Encyclopedia
Endocrine Surgery Encyclopedia
Anaplastic thyroid carcinoma is an aggressive form of cancer of the thyroid gland.
Alternative Names: Anaplastic carcinoma of the thyroid
Causes, incidence, and risk factors:
Anaplastic thyroid cancer grows very rapidly and is an invasive type of thyroid cancer.
It occurs most often in people over age 60. The cause is unknown. Thyroid function
tests are usually normal. Anaplastic cancer accounts for only about 1% of all thyroid
cancers and is a very rare disease.
- Lower neck mass, often noted to be enlarging
- Hoarseness or changing voice
- Coughing up blood
- Difficulty swallowing
- Loud breathing
Signs and tests:
A physical examination may show a neck mass.
- A thyroid biopsy shows anaplastic carcinoma
- An isotope study of the thyroid (thyroid scan) shows this mass to be "cold",
meaning it does not absorb the isotope.
- A CT scan or MRI may show a tumor growing from the thyroid gland.
- An examination of the airway with a fiberoptic scope (laryngoscopy) may show
a paralyzed vocal cord.
This type of cancer is treated with surgery to remove the tumor, or radiation therapy,
or both. Surgery may require placement of a tube in the throat to help breathing
(tracheostomy). This tumor is not responsive to radioactive iodine, which is used
to treat other types of thyroid cancer. It is also usually not responsive to chemotherapy.
The stress of illness can often be eased by joining a support group of people sharing
common experiences and problems. See cancer - support group.
The prognosis of this disease is poor. Less than 5% of patients survive 5 years.
Most people do not survive longer than 6 months.
- Spread of tumor within the neck
- Metastasis (spread) of cancer to other body tissues or organs
Calling your health care provider:
Call your health care provider if there is a persistent lump or mass in the neck,
hoarseness, changing voice, cough or coughing up blood.
Review Date: 5/26/2006
Reviewed By: Rita Nanda, M.D., Department of Medicine, Section of Hematology/Oncology,
University of Chicago Medical Center, Chicago, IL. Review provided byVeriMed Healthcare
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